Alfons Maria Jakob (2 July 1884 – 17 October 1931) was a German

neurologist Neurology (from el, νεῦρον (neûron), "string, nerve" and the suffix -logia, "study of") is the branch of medicine dealing with the diagnosis and treatment of all categories of conditions and disease involving the brain, the spinal c ...

who worked in the field of

neuropathology Neuropathology is the study of disease of nervous system tissue, usually in the form of either small surgical biopsies or whole-body autopsies. Neuropathologists usually work in a department of anatomic pathology, but work closely with the clinic ...

. He was born in

Aschaffenburg Aschaffenburg (; South Franconian: ''Aschebersch'') is a town in northwest Bavaria, Germany. The town of Aschaffenburg is not part of the district of Aschaffenburg, but is its administrative seat. Aschaffenburg belonged to the Archbishopric ...

Bavaria Bavaria ( ; ), officially the Free State of Bavaria (german: Freistaat Bayern, link=no ), is a state in the south-east of Germany. With an area of , Bavaria is the largest German state by land area, comprising roughly a fifth of the total lan ...

and educated in

medicine Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care pract ...

at the universities of

Munich Munich ( ; german: München ; bar, Minga ) is the capital and most populous city of the States of Germany, German state of Bavaria. With a population of 1,558,395 inhabitants as of 31 July 2020, it is the List of cities in Germany by popu ...

Berlin Berlin ( , ) is the capital and largest city of Germany by both area and population. Its 3.7 million inhabitants make it the European Union's most populous city, according to population within city limits. One of Germany's sixteen constitue ...

, and

Strasbourg Strasbourg (, , ; german: Straßburg ; gsw, label=Bas Rhin Alsatian, Strossburi , gsw, label=Haut Rhin Alsatian, Strossburig ) is the prefecture and largest city of the Grand Est region of eastern France and the official seat of the Eu ...

, where he received his doctorate in 1908. During the following year, he began clinical work under the

psychiatrist A psychiatrist is a physician who specializes in psychiatry, the branch of medicine devoted to the diagnosis, prevention, study, and treatment of mental disorders. Psychiatrists are physicians and evaluate patients to determine whether their sy ...

Emil Kraepelin Emil Wilhelm Georg Magnus Kraepelin (; ; 15 February 1856 – 7 October 1926) was a German psychiatrist. H. J. Eysenck's ''Encyclopedia of Psychology'' identifies him as the founder of modern scientific psychiatry, psychopharmacology and psychi ...

and did laboratory work with

Franz Nissl Franz Alexander Nissl (9 September 1860, in Frankenthal – 11 August 1919, in Munich) was a German psychiatrist and medical researcher. He was a noted neuropathologist. Early life Nissl was born in Frankenthal to Theodor Nissl and Maria Haas ...

and

Alois Alzheimer Alois Alzheimer ( , , ; 14 June 1864 – 19 December 1915) was a German psychiatrist and neuropathologist and a colleague of Emil Kraepelin. Alzheimer is credited with identifying the first published case of "presenile dementia", which Kraepel ...

.Alfons Maria Jakob
at

Who Named It ''Whonamedit?'' is an online English-language dictionary of medical eponyms and the people associated with their identification. Though it is a dictionary, many eponyms and persons are presented in extensive articles with comprehensive bibliograph ...

In 1911, by way of an invitation from

Wilhelm Weygandt Wilhelm Christian Jakob Karl Weygandt (30 September 1870 in Wiesbaden – 22 January 1939) was a German psychiatrist. From 1908-1934, he was director of the insane asylum Staatskrankenanstalt Friedrichsberg in Hamburg, and from 1919-1934 profes ...

,Neurological Eponyms
edited by Peter J. Koehler, George W. Bruyn, John M. S. Pearce he relocated to

Hamburg (male), (female) en, Hamburger(s), Hamburgian(s) , timezone1 = Central (CET) , utc_offset1 = +1 , timezone1_DST = Central (CEST) , utc_offset1_DST = +2 , postal ...

, where he worked with Theodor Kaes and eventually became head of the laboratory of

anatomical pathology Anatomical pathology (''Commonwealth'') or Anatomic pathology (''U.S.'') is a medical specialty that is concerned with the diagnosis of disease based on the macroscopic, microscopic, biochemical, immunologic and molecular examination ...

at the psychiatric State Hospital Hamburg-Friedrichsberg. Following the death of Kaes in 1913, Jakob succeeded him as

prosector A prosector is a person with the special task of preparing a dissection for demonstration, usually in medical schools or hospitals. Many important anatomists began their careers as prosectors working for lecturers and demonstrators in anatomy and p ...

. During

World War I World War I (28 July 1914 11 November 1918), often abbreviated as WWI, was one of the deadliest global conflicts in history. Belligerents included much of Europe, the Russian Empire, the United States, and the Ottoman Empire, with fightin ...

he served as an army physician in Belgium, and afterwards returned to Hamburg. In 1919, he obtained his

habilitation Habilitation is the highest university degree, or the procedure by which it is achieved, in many European countries. The candidate fulfills a university's set criteria of excellence in research, teaching and further education, usually including a ...

for

neurology Neurology (from el, wikt:νεῦρον, νεῦρον (neûron), "string, nerve" and the suffix wikt:-logia, -logia, "study of") is the branch of specialty (medicine), medicine dealing with the diagnosis and treatment of all categories of co ...

and in 1924 became a professor of neurology. Under Jakob's guidance the department grew rapidly. He made significant contributions to knowledge on

concussion A concussion, also known as a mild traumatic brain injury (mTBI), is a head injury that temporarily affects brain functioning. Symptoms may include loss of consciousness (LOC); memory loss; headaches; difficulty with thinking, concentration, ...

and secondary nerve degeneration and became a doyen of

.The Man Behind the Syndrome
by Greta Beighton Jakob was the author of five monographs and nearly 80 scientific papers. His neuropathological research contributed greatly to the delineation of several diseases, including

multiple sclerosis Multiple (cerebral) sclerosis (MS), also known as encephalomyelitis disseminata or disseminated sclerosis, is the most common demyelinating disease, in which the insulating covers of nerve cells in the brain and spinal cord are damaged. This d ...

and

Friedreich's ataxia Friedreich's ataxia (FRDA or FA) is an autosomal-recessive genetic disease that causes difficulty walking, a loss of sensation in the arms and legs, and impaired speech that worsens over time. Symptoms generally start between 5 and 20 year ...

. He first recognised and described

Alper's disease Mitochondrial DNA depletion syndrome (MDS or MDDS), or Alper's disease, is any of a group of autosomal recessive disorders that cause a significant drop in mitochondrial DNA in affected tissues. Symptoms can be any combination of myopathic, hepat ...

and

Creutzfeldt–Jakob disease Creutzfeldt–Jakob disease (CJD), also known as subacute spongiform encephalopathy or neurocognitive disorder due to prion disease, is an invariably fatal degenerative brain disorder. Early symptoms include memory problems, behavioral changes, ...

(named along with Munich neuropathologist

Hans Gerhard Creutzfeldt Hans Gerhard Creutzfeldt (June 2, 1885 – December 30, 1964) was a German neurologist and neuropathologist. Although he is typically credited as the physician to first describe the Creutzfeldt–Jakob disease, this has been disputed. He was bor ...

). He gained experience in

neurosyphilis Neurosyphilis refers to infection of the central nervous system in a patient with syphilis. In the era of modern antibiotics the majority of neurosyphilis cases have been reported in HIV-infected patients. Meningitis is the most common neurologic ...

, having a 200-bed ward devoted entirely to that disorder. Jakob made a lecture tour of the United States (1924) and South America (1928), of which, he wrote a paper on the neuropathology of

yellow fever Yellow fever is a viral disease of typically short duration. In most cases, symptoms include fever, chills, loss of appetite, nausea, muscle pains – particularly in the back – and headaches. Symptoms typically improve within five days. In ...

. He suffered from chronic

osteomyelitis Osteomyelitis (OM) is an infection of bone. Symptoms may include pain in a specific bone with overlying redness, fever, and weakness. The long bones of the arms and legs are most commonly involved in children e.g. the femur and humerus, while the ...

for the last seven years of his life. This eventually caused a retroperitoneal

abscess An abscess is a collection of pus that has built up within the tissue of the body. Signs and symptoms of abscesses include redness, pain, warmth, and swelling. The swelling may feel fluid-filled when pressed. The area of redness often extends b ...

and

paralytic Paralysis (also known as plegia) is a loss of motor function in one or more muscles. Paralysis can also be accompanied by a loss of feeling (sensory loss) in the affected area if there is sensory damage. In the United States, roughly 1 in 50 ...

ileus Ileus is a disruption of the normal propulsive ability of the intestine. It can be caused by lack of peristalsis or by mechanical obstruction. The word 'ileus' is from Ancient Greek ''eileós'' (, "intestinal obstruction"). The term 'subileus' re ...

from which he died following operation.

Associated eponym

: A very rare and incurable degenerative neurological disease. It is the most common form of

transmissible spongiform encephalopathies Transmissible spongiform encephalopathies (TSEs) are a group of progressive and fatal conditions that are associated with prions and affect the brain and nervous system of many animals, including humans, cattle, and sheep. According to the most ...

caused by

prion Prions are misfolded proteins that have the ability to transmit their misfolded shape onto normal variants of the same protein. They characterize several fatal and transmissible neurodegenerative diseases in humans and many other animals. It ...

s. Eponym introduced by

Walther Spielmeyer Walther Spielmeyer (23 April 1879 – 6 February 1935) was a German neuropathologist who was a native of Dessau. Biography He studied medicine at the University of Halle as a student of Eduard Hitzig (1838-1907). At Halle he was influenced b ...

in 1922.

Bibliography

* ''Die extrapyramidalen Erkrankungen''. In: ''Monographien aus dem Gesamtgebiete der Neurologie und Psychiatry'', Berlin, 1923 * ''Normale und pathologische Anatomie und Histologie des Grosshirns''. Separate printing of ''Handbuch der Psychiatry''. Leipzig, 1927–1928 * ''Das Kleinhirn''. In: ''Handbuch der mikroskopischen Anatomie'', Berlin, 1928 * ''Die Syphilis des Gehirns und seiner Häute''. In:

Oswald Bumke Oswald Bumke (25 September 1877 – 5 January 1950) was a German psychiatrist and neurologist. Family Bumke's mother, Emma (1850 - 1914), was the daughter of a factory owner. His father, Albert Bumke (1843-1892), was a physician and assistant ...

(edit.): ''Handbuch der Geisteskrankheiten'', Berlin, 1930.Alfons Maria Jakob - bibliography
at Who Named It

References

{{DEFAULTSORT:Jakob, Alfons Maria People from Aschaffenburg Academic staff of the University of Hamburg German neurologists German neuroscientists 1884 births 1931 deaths